相关实验视频

Updated: Jun 12, 2025

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Multiplexing Focused Ultrasound Stimulation with Fluorescence Microscopy

Published on: January 7, 2019

使用聚焦超声波来增强液体活检的使用

Ying Meng¹, Christopher B Pople², Nir Lipsman¹

¹Division of Neurosurgery, Sunnybrook Health Sciences Centre, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, Canada; Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, University of Toronto Canada, 2075 Bayview Avenue, Toronto, Ontario, Canada.

Magnetic resonance imaging clinics of North America

|September 25, 2024

概括

聚焦超声波 (FUS) 可以暂时打开血脑屏障,从而有可能通过液体活检检测大脑生物标志物. 本综述探讨了这种创新诊断方法的证据和挑战.

科学领域:

医学成像医学成像
超声波技术的超声波技术
神经学神经学

背景情况:

医学成像和超声波传感器设计的进步使得聚焦超声波 (FUS) 能够用于内应用.
FUS研究的一个关键领域是血脑屏障 (BBB) 的暂时破坏.
由FUS引起的BBB中断超出了药物输送的范围,包括生物标志物释放.

研究的目的:

审查目前支持FUS用于液体活检的证据.
识别和讨论推动FUS介导液体活检的挑战.
探索FUS的潜力,以促进大脑生物标志物的检测.

主要方法:

对集中式超声波和血脑屏障破坏现有研究的文献综述.
对用于诊断目的的FUS启用生物标志物释放的证据分析.
在FUS液体活检的开发中识别技术和临床障碍.

主要成果:

聚焦超声波显示,它有望暂时打开血脑屏障.
这种BBB中断可能会使特定的大脑生物标志物释放到循环中.
空间特异性是FUS在生物标志物检测中提供的关键优势.

结论:

由FUS介导的血脑屏障破坏为非侵入性脑生物标志物检测 (液体活检) 提供了一种新的方法.
为了克服当前的挑战,需要进一步的研究和技术进步.
FUS液体活检有可能改善神经疾病的诊断和监测.

关键词:

血脑屏障的破坏血脑屏障的破坏聚焦式超声波的使用方法液体活检液体活检

更多相关视频

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Generation and Quantitative Analysis of Pulsed Low Frequency Ultrasound to Determine the Sonic Sensitivity of Untreated and Treated Neoplastic Cells

Published on: July 22, 2015

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Evaluation of the Feasibility, Safety, and Accuracy of an Intraoperative High-intensity Focused Ultrasound Device for Treating Liver Metastases

Published on: January 9, 2019

相关概念视频

Ultrasound II: Endoscopic Ultrasound and FibroScan

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

Ultrasonography

Ultrasonography

Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...