Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Spinal Cord: Cross-sectional Anatomy01:16

Spinal Cord: Cross-sectional Anatomy

1.8K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray...
1.8K
Cerebrum: Anatomical Overview II01:11

Cerebrum: Anatomical Overview II

1.6K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.6K
Prosopagnosia01:24

Prosopagnosia

144
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
144

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Human brain matters: Navigating the neuropathology of COVID-19.

Brain pathology (Zurich, Switzerland)·2026
Same author

Expanding the Clinicoradiologic Phenotype of the <i>CTSA</i>-Associated Small Vessel Disease CARASAL: A Comparison With CADASIL.

Neurology. Genetics·2026
Same author

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema.

Annals of clinical and translational neurology·2026
Same author

Hypomyelination of Early Myelinating Brain Structures.

Neuropediatrics·2026
Same author

Quantitative measures of total and phosphorylated alpha-synuclein in skin tissue as potential biomarkers for synucleinopathies.

Journal of Parkinson's disease·2026
Same author

Multi-omics investigation of thyroid development and dysfunction in down syndrome.

Human molecular genetics·2026
Same journal

Preface.

Handbook of clinical neurology·2026
Same journal

Foreword.

Handbook of clinical neurology·2026
Same journal

Fundus autofluorescence imaging.

Handbook of clinical neurology·2026
Same journal

The electroretinogram as a means to study the physiology of the retina.

Handbook of clinical neurology·2026
Same journal

Adaptive optics scanning light ophthalmoscopy.

Handbook of clinical neurology·2026
Same journal

Modeling the human retina in a dish: Advances and future directions.

Handbook of clinical neurology·2026
查看所有相关文章

相关实验视频

Updated: Jun 12, 2025

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.2K

消失的白质物质消失了

Marjo S van der Knaap1, Marianna Bugiani2, Truus E M Abbink3

  • 1Department of Child Neurology, Amsterdam Leukodystrophy Center, Emma Children's Hospital, Amsterdam University Medical Center, and Amsterdam Neuroscience, Cellular & Molecular Mechanisms, Vrije Universiteit, Amsterdam, The Netherlands.

Handbook of clinical neurology
|September 25, 2024
PubMed
概括
此摘要是机器生成的。

消失白质 (VWM) 是一种罕见的白血病,由eIF2B基因变异引起. 针对eIF2B通路和星细胞中综合应激反应可能为VWM提供新的治疗策略.

关键词:
星球细胞是星球细胞.细胞启动因子2B (eIF2B) 是一个综合应激反应 (ISR) 是一种综合应激反应.氧基质细胞 (Oligodendrocytes) 是一种类型的质细胞.卵巢衰竭发生在卵巢中.消失的白物质 (VWM)

更多相关视频

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

相关实验视频

Last Updated: Jun 12, 2025

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
16:23

Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation

Published on: May 23, 2017

11.2K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

28.4K

科学领域:

  • 神经科学是一个神经科学.
  • 遗传学 是一个遗传学.
  • 细胞生物学 细胞生物学

背景情况:

  • 消失白质 (VWM) 是一种严重的白血病,发病和进展各不相同.
  • 它是由真核启动因子2B (eIF2B) 基因的致病变异引起的,影响白质和星体细胞.
  • 对于中枢神经系统白质和卵巢的选择性脆弱性仍然不太了解.

研究的目的:

  • 研究eIF2B在VWM中综合应激反应 (ISR) 中的作用.
  • 探索在VWM病原体中的星细胞中ISR的特定激活.
  • 通过调节eIF2B活动和ISR来确定潜在的治疗点.

主要方法:

  • 与eIF2B功能障碍相关的VWM病原体的分析.
  • 在VWM模型中研究星体细胞中的ISR激活.
  • 在VWM小鼠模型中评估治疗潜力.

主要成果:

  • eIF2B中的遗传变异导致活动减少和构成性ISR激活.
  • 在VWM中,ISR在星球细胞中被特别激活.
  • 调节eIF2B活动和ISR影响VWM小鼠模型中的疾病严重程度.

结论:

  • eIF2B是ISR的关键调节者,其功能障碍驱动着VWM的发病.
  • 针对星细胞中的eIF2B调节通路和ISR,为VWM提供了一个有希望的治疗途径.