发烧的幼儿和与肠道病毒感染的关联
Ya-Li Hu1, Ai-Ling Cheng2, Shun-Hua Chen3
1Department of Pediatrics, Cathay General Hospital, Taipei, Taiwan; Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Journal of the Formosan Medical Association = Taiwan yi zhi
|September 25, 2024
概括
肠道病毒感染影响17.4%的发烧婴儿,早期发病病例带来更高的风险. 早期检测和测试对于管理幼儿严重肠道病毒感染至关重要.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 肠道病毒是儿童疾病的常见原因,但对其对幼儿的影响的数据有限.
- 这项研究解决了了解肠道病毒在发烧婴儿中的作用的差距,并确定了严重结果的危险因素.
研究的目的:
- 为了确定90天以下发烧的婴儿中肠道病毒的患病率.
- 在这个人群中确定与严重肠道病毒感染相关的危险因素.
主要方法:
- 从2010年到2021年,研究了一组840名90天以下的发烧婴儿.
- 使用病毒隔离或泛肠道病毒PCR确认了肠道病毒感染.
- 严重的并发症包括败血症,中枢神经系统参与,休克,肝功能衰竭和死亡率.
主要成果:
- 在发烧的婴儿中有17.4%检测到肠道病毒; 46%患有脑膜炎/脑炎.
- 早期发病的感染 (在生命的2周内) 与贫血相关,ICU入院,中枢神经系统参与,休克,肝功能衰竭和死亡率.
- 高风险血清型和低血红蛋白 (<9 g/dL) 是严重并发症的显著预测因素.
结论:
- 肠道病毒占幼儿发烧疾病的17.4%,病例死亡率为2%.
- 建议对发烧的婴儿及时进行病毒培养或PCR测试,这些婴儿有肠道病毒感染的危险因素.
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