新生儿脑病变:报告治疗结果的系统审查
Fiona Quirke1,2, Linda Biesty3,4, Malcolm Battin5
1Neonatal Encephalopathy PhD Training Network, Health Research Board, Dublin, Ireland 22306056@studentmail.ul.ie.
BMJ paediatrics open
|September 25, 2024
概括
新生儿脑病变 (NE) 治疗研究报告了许多不同的结果,使得比较变得困难. 为了在NE研究中提供一致的报告,需要与家长输入的核心结果集 (COS).
科学领域:
- 新生儿研究新生儿研究
- 临床试验方法论 临床试验方法论
- 神经发育障碍 神经发育障碍
背景情况:
- 新生儿脑病变 (NE) 是一种严重的疾病,具有显著的死亡率和长期神经发育残疾风险.
- 治疗性低温是标准的NE治疗,但持续性损伤很常见.
- 在NE治疗研究中结果测量的变化阻碍了研究综合.
研究的目的:
- 识别和分类随机试验中报告的结果和对NE干预措施的系统审查.
- 为开发NE治疗研究的核心成果集 (COS) 提供信息.
- 为解决NE干预结果报告中的异质性.
主要方法:
- 在多个数据库 (MEDLINE,Embase,Cochrane CENTRAL) 和注册表中进行系统的文献搜索.
- 两位评论员对文章进行独立选.
- 逐字提取,对相似结果进行分组,并开发结果域.
主要成果:
- 在85项研究中的116篇论文中,共确定了386个不同的结果.
- 结果被分为18个不同的领域.
- 没有一个单一的结果被普遍报告,突出显著的异质性;父母的投入没有明确记录.
结论:
- 报告结果的广泛变化使得对NE治疗的证据综合复杂化.
- 一个标准化的核心成果集 (COS),包括家长和家庭的观点,是必不可少的.
- 实施COS将提高结果测量和报告的一致性,促进随机试验的可靠比较.
关键词:
新生儿科学 新生儿科学相关概念视频
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