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Updated: Jun 12, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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设计的诱导内细胞分裂的蛋白质降解目标并放大信号

Buwei Huang1,2,3, Mohamad Abedi1,2, Green Ahn4

  • 1Department of Biochemistry, University of Washington, Seattle, WA, USA.

Nature
|September 25, 2024
PubMed
概括

研究人员开发了新的计算设计方法来触发内细胞结合蛋白 (EndoTags). 这些EndoTags促进向蛋白质降解和信号激活,为各种疾病提供显著的治疗潜力.

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