在儿科患者群体中,液体基尿素输送计划的坚持结果
Maria A Sacta1,2,3, Supriya Sarvode1,2,4, Amanuel Kehasse5
1Department of Pediatrics, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts, USA.
Pediatric blood & cancer
|September 26, 2024
概括
液态氧尿素 (LHU) 的家庭配送显著减少了儿科状细胞病患者的住院治疗和急性胸部综合征. 这项计划改善了药物坚持和获取,提高了患者的治疗结果.
科学领域:
- 儿科血液学 儿科血液学
- 状细胞疾病管理管理
- 药理干预药理干预
背景情况:
- 在儿科状细胞病 (SCD) 患者中,素尿素的利用不足.
- 药物补充剂和液体配方的获取是氧尿素坚持的关键障碍.
- 研究了复合液态氧尿素 (LHU) 的家庭配送,以解决这些障碍.
研究的目的:
- 为了确定家庭交付复合LHU对儿科SCD患者的临床影响.
- 评估药物坚持和急性护理利用率的变化.
- 评估LHU家庭分娩在改善SCD管理方面的有效性.
主要方法:
- 在2016年3月至2020年7月接受LHU的儿科患者 (<21岁) 的回顾性队列研究.
- 使用电子健康记录和药房数据库.
- 通过覆盖日数 (PDC) 的比例评估药物坚持,并分析LHU计划入学前后的急性护理利用率.
主要成果:
- 41名患者的队列在LHU启动后显著减少了住院 (p=0.01) 和急性胸部综合征发作 (p=0.03).
- 之前服用基尿素的患者住院率较低,血管封闭性事件 (VOE) 较少,急救诊所访问较少.
- 在LHU启动1年后的PDC中位数为95%.
结论:
- 复合LHU的家庭配送改善了儿科SCD患者获得基尿素的机会.
- 该LHU家庭分娩计划与减少住院和急性胸部综合征有关.
- 这种交付模式可以节省成本并改善患者的治疗结果,从而增强SCD护理.
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