了解全球获取局部阴性菌病治疗:系统性审查和元分析
S M Nasereddin1,2, J L Li2, O S Malallah2
1College of Pharmacy, Amman Arab University, Mubis, Jordan.
Mycoses
|September 26, 2024
概括
获得有效的局部形菌根治疗是一种全球性问题,90%的国家缺乏最有效的选择. 这凸显了抗真菌药物可用性的差异,并强调了需要更广泛地获得治疗的必要性.
科学领域:
- 皮肤病学和传染病学
- 药物经济学和公共卫生
背景情况:
- 公平获取药品对于公共卫生至关重要,但对于像牛皮病这样的动态感染来说,测量是具有挑战性的.
- 这项研究通过综合感染流行率,药物有效性和监管可用性来评估获得局部桃病药物的机会.
研究的目的:
- 评估全球获得有效的局部形球菌瘤治疗的机会.
- 确定导致获取差异的因素,包括病原体流行率和药物可用性.
主要方法:
- 1990-2019年间从PubMed和Web of Science发表的研究的系统文献综述和元分析.
- 包括使用聚合酶连锁反应 (PCR) 分析进行的人体桃菌病研究.
- 分析采用了一个随机效应模型,使用弗里曼-图基转换来确定全球感染趋势和区域病原体差异.
主要成果:
- 在26项研究中,PCR在55%的视觉怀疑病例中证实了形菌根症.
- 皮肤菌是最常见的病原体 (57%),但酵母在女性,指甲感染和干旱地区占主导地位.
- 90%的评估国家居民无法获得最有效的局部产品;22%的人无法获得任何广泛的药物,非洲是获得最差的国家.
结论:
- 获得有效的局部形菌根治疗是全球面临的重大挑战.
- 在临床研究中Candida感染的代表性不足可能会导致访问问题.
- 需要进一步的研究,包括对象对象对象试验的药物,如efinaconazole,以改善治疗机会.
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