细胞和离子导电量有助于膀和尿道光滑肌肉的自发活动
Bernard T Drumm1, Neha Gupta1, Alexandru Mircea1
1Smooth Muscle Research Centre, Department of Life & Health Science, Dundalk Institute of Technology, Dundalk, Ireland.
The Journal of physiology
|September 26, 2024
概括
下泌尿道光滑肌细胞表现出不同的尿液储存和排泄机制. 尿道光滑肌细胞 (USMCs) 本质上是收缩的节奏,而膀排泄器光滑肌细胞 (DSMCs) 则依赖电压依赖的流入.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 顺滑肌肉生理学 顺滑肌肉生理学
- 细胞电生理学 细胞电生理学
背景情况:
- 下部泌尿道,包括膀排泄器和尿道壁,包括在尿液储存和排尿期间具有互惠收缩功能的光滑肌肉器官.
- 排尿器光滑肌细胞 (DSMCs) 放松以适应膀的填充,而尿道光滑肌细胞 (USMCs) 保持尿道关闭的音调.
研究的目的:
- 为了研究底层平滑肌肉活动的细胞机制在下泌尿道.
- 区分DSMC和USMC的内在节律性和收缩调节.
主要方法:
- 来自USMC和DSMC的各种物种的电生理记录.
- 对 (Ca2+) 动态和细胞信号通路的分析.
- 调查干细胞参与光滑肌肉节奏的研究.
主要成果:
- 美国MCs表现出内在的细胞节律性,产生传播Ca2+波,这些波的总和产生尿道音调,独立于电压依赖的机制.
- DSMC显示自发的短暂收缩和动作潜力,由电压依赖的Ca2+流入驱动.
- 尿道中的间歇性细胞与Cajal的胃肠间歇性细胞具有共同的特征,而膀间歇性细胞 (PDGFRα+) 可能会负面调节DSMC活动.
结论:
- 尿道光滑肌肉度主要是由USMCs内Ca2+调动通路的内在节奏决定的.
- 膀排泄器平滑肌的收缩依赖于电压依赖的Ca2+流入,具有专门的间歇细胞可能调节刺激性.
- 在下泌尿道生理学中,不同的细胞机制控制尿道和排尿器光滑肌的功能.
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