AESurv:自编码器生存分析用于准确预测冠心病的早期预测
Yike Shen1,2, Arce Domingo-Relloso3,4,5, Allison Kupsco2
1Department of Earth and Environmental Sciences, University of Texas at Arlington, 500 Yates Street, Arlington, TX, 76019, USA.
Briefings in bioinformatics
|September 26, 2024
概括
我们开发了AESurv,这是一个使用DNA甲基化和临床数据进行准确冠心病 (CHD) 预测的深度学习模型. 这种先进的模型有助于早期干预心血管疾病风险的策略.
科学领域:
- 生物医学信息学 生物医学信息学
- 心血管疾病研究研究
- 基因组学和表观遗传学
背景情况:
- 冠心病 (CHD) 是美国的主要死亡原因.
- 早期预测心血管疾病对于有效干预至关重要.
- 高维数据,包括DNA甲基化,为改善风险预测提供了潜力.
研究的目的:
- 开发和验证一种新的深度学习模型,用于预测冠心病的时间到事件.
- 将高维的DNA甲基化数据与临床风险因素相结合,以提高预测准确度.
- 将拟议模型的性能与现有的生存分析方法进行比较.
主要方法:
- 开发了一个深度学习自编码器生存分析模型 (AESurv).
- 利用高维的血液DNA甲基化特征和传统的临床风险因素.
- 将该模型应用于两个前性队列研究:强心研究 (SHS) 和妇女健康倡议 (WHI).
主要成果:
- AESurv有效地学习了参与者的低维表示.
- 与其他模型相比,在SHS队列中实现了优异的预测性能 (C指数:0.864 ± 0.009,AUROC:0.905 ± 0.009).
- 在WHI队列中验证了优异的表现,证明了可概括性.
结论:
- 该AESurv模型提供了准确的时间到事件的CHD预测.
- 将DNA甲基化数据与临床因素相结合,提高了预测能力.
- AESurv可以帮助医疗保健专业人员和患者制定心脏病早期干预策略.
更多相关视频
10:03Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
5.2K
07:25Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
Published on: September 22, 2020
3.4K
相关概念视频
01:09Censoring Survival Data
69
Survival analysis is a statistical method used to analyze time-to-event data, often employed in fields such as medicine, engineering, and social sciences. One of the key challenges in survival analysis is dealing with incomplete data, a phenomenon known as "censoring." Censoring occurs when the event of interest (such as death, relapse, or system failure) has not occurred for some individuals by the end of the study period or is otherwise unobservable, and it might have many different...
69
01:30Coronary Artery Disease I: Introduction
3
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
3
01:21Cancer Survival Analysis
331
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
331
01:27Coronary Artery Disease V: Surgical Management
3
Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
3
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
3
Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
3
01:30Acute Coronary Syndrome III: Diagnostic studies
3
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
3