缺铁及其与慢性心力衰竭的关系 - - 综述
Arshdeep Kaur1, Ranjeet Kumar1
1Department of Pharmacy Practice, ISF College of Pharmacy, Moga, Ghal Kalan, Punjab, 142048, India.
Cardiovascular & hematological agents in medicinal chemistry
|September 26, 2024
概括
慢性心力衰竭 (CHF) 患者常见的缺铁 (ID) 是慢性心力衰竭 (CHF),恶化的结果. 建议对ID进行查,但由于副作用和有效性有限,不建议患者服用口服铁补充剂.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 血液学 血液学 血液学
背景情况:
- 铁缺乏症 (ID) 在患有心血管疾病的患者中非常普遍,特别是慢性心力衰竭 (CHF).
- 随着心脏和功能障碍的严重程度,ID的发病率会升级,不成比例地影响女性.
- 全球超过6400万人患有慢性心力衰竭,这突显了这种疾病的广泛影响.
研究的目的:
- 审查多因素病理生理学,将临床特征,功能性和绝对的ID联系起来,以及医疗干预在CHF中的好处.
- 阐明缺铁超出心脏功能的系统性影响.
- 检查当前基于证据的治疗方法和CHF中ID的诊断指南.
主要方法:
- 对最近的出版物进行了系统的审查.
- 研究包括了大量关于CHF和ID之间存在关联的科学数据,有或没有贫血.
- 重点是确定有关病理生理学,临床特征和治疗干预措施的相关研究.
主要成果:
- 复杂的生理病理相互作用,包括肝激素升高,全身炎症和氨酸- ангиотензин- 氨酸系统激活,都涉及到心血管疾病患者.
- 这些机制加剧了贫血,心血管衰竭和慢性病 (CKD) 的严重程度,对患者的治疗结果产生了负面影响.
- 关于治疗疗效和诊断指南的研究结果仍然有限,有时不一致.
结论:
- 贫血是心血管衰竭的常见并发症和不良预后指标.
- 铁缺乏症查对于心脏病患者至关重要,因为它的预后意义.
- 由于胃肠道副作用和血红蛋白反应缓慢,一般不建议患者服用口服铁补充剂;可以考虑静脉注射铁.
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