外源性症减轻了急性山病,并缓解了高海拔正常性低氧症
Myrthe Stalmans1, Domen Tominec2, Wout Lauriks1
1Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium.
Journal of applied physiology (Bethesda, Md. : 1985)
|September 26, 2024
概括
乙烯 (KE) 摄入有助于预防高海拔地区的急性山病 (AMS). 这种饮食改变改善了氧气水平,并通过减轻低氧化和增加同情活动来减少AMS症状.
科学领域:
- 身体生理学 身体生理学
- 高度医学 高度医学
- 营养科学 营养科学
背景情况:
- 急性山病 (AMS) 是高海拔地区常见的疾病,主要是由低氧化症引起的.
- 外源乙醇 (KE) 已显示出减轻低氧化症的潜力,这表明它可能在缓解AMS方面发挥作用.
研究的目的:
- 调查KE摄入引起的外源症是否可以减轻AMS的发展.
- 确定负责任何观察到的AMS缓解的潜在生理机制.
主要方法:
- 在交叉设计中,14名健康的男性接受了两个29小时的模拟高空 (4,000-4,500米) 协议.
- 参与者定期接受KE或安慰剂 (CON),并监测生理反应.
- 在严重的AMS发展 (Lake Louise分数≥10) 后,协议被终止.
主要成果:
- 与安慰剂组 (<0.6 mM) 不同的是,KE摄入持续诱导症 (∼3 mM d-β-hydroxybutyrate),而不是安慰剂组 (<0.6 mM).
- 协议持续时间在KE中延长了32%,并且在患有严重AMS的参与者中翻了一番.
- 与安慰剂相比,KE减轻了渐进性低氧化,改善了大脑氧化,增加了同情主导地位.
结论:
- 通过摄入KE的外源症有效地减轻了急性山病的发展.
- 关键机制包括改善动脉和大脑氧化,减少大脑血流,增强同情力驱动.
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