穆皮罗辛药膏对鼻手术后多发症复发的影响
Alireza Mohebbi1, Maryam Mohsenian1, Morvarid Elahi1
1ENT and Head & Neck Research Center, Hazrat Rasoul Hospital/ The Five Health Senses Institute, Iran University of Medical Sciences, Tehran, Iran.
Iranian journal of otorhinolaryngology
|September 26, 2024
概括
局部应用到鼻腔前庭的mupirocin膏在手术后患有鼻息肉的慢性鼻炎的患者中没有显著地防止症状复发. 需要进一步的研究来探索黄金葡萄球菌的替代治疗方法.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 外科手术的结果
背景情况:
- 黄金葡萄球菌 (Staphylococcus aureus) 是一个关键的病原体,与患有长期鼻炎和鼻的患者的症状复发有关.
- 有效的管理策略对于减少症状复发和改善这些患者手术结果至关重要.
研究的目的:
- 调查局部mupirocin膏在鼻腔前庭的有效性,以减少症状的复发.
- 评估mupirocin对功能性内镜外科手术结果效率的影响.
主要方法:
- 进行了一项临床试验,涉及慢性鼻炎,鼻和阳性黄金菌鼻菌培养的患者.
- 穆皮罗辛药膏应用于右鼻孔 (干预),而维生素A药膏应用于左鼻孔 (控制).
- 在手术前和后评估了隆德-麦凯放射学和隆德-肯尼迪内镜评分.
主要成果:
- 在60名参与者中,超过90%的参与者呈阳性黄金葡萄球菌鼻腔培养.
- 干预组和对照组在手术后的放射学和内镜分数显著改善 (P<0.001).
- 在mupirocin和维生素A组 (P>0.56) 之间没有观察到得分改善的显著差异.
结论:
- 在内镜鼻腔外科手术后鼻腔应用mupirocin并没有显著减少慢性鼻炎与鼻的症状复发.
- 这些发现表明,mupirocin不是有效的预防药物,可以预防这种患者群体中黄金葡萄球菌相关症状的复发.
更多相关视频
相关概念视频
Epistaxis
140
Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...
140
Tonsillitis II: Management
104
This lesson will focus on the different treatment options for managing tonsillitis, which typically depend on the cause and severity.
104
Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
414
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
414
Inflammatory Bowel Disease V: Surgical Management
128
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
128
Drugs for Peptic Ulcer Disease: Prostaglandin Analogs as Mucosal Protective Agents
375
The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
Non-steroidal anti-inflammatory drugs (NSAIDs) can induce peptic ulcers by inhibiting cyclooxygenase, decreasing...
375
Peptic Ulcer Disease IV: Management
74
Medical treatment strategies for peptic ulcers encompass various methods. The primary goal of treatment is to diminish gastric acidity and strengthen mucosal defense mechanisms.
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
74


