超越基因组:解读MALAT1在乳腺癌进展中的作用
Md Sadique Hussain1, Mohit Agrawal2, Nusratbanu K Shaikh3
1School of Pharmaceutical Sciences, Jaipur National University, Jaipur, Rajasthan (302017), India.
Current genomics
|September 26, 2024
概括
马拉特1长非编码RNA在乳腺癌 (BC) 进展中起着关键作用,影响侵袭,转移和治疗耐药性. 了解马拉特1语言1
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 乳腺癌 (BC) 是一个全球性的健康问题,需要更深入的分子理解.
- 长非编码RNAs (lncRNAs) 正在成为癌症的关键调节者.
- 转移相关的肺腺癌转录1 (MALAT1) 是一个突出的lncRNA,涉及到各种细胞功能.
研究的目的:
- 审查MALAT1在乳腺癌进展中的多方面的作用和分子相互作用.
- 阐明MALAT1在关键的瘤性过程中的参与.
- 突出MALAT1作为生物标志物和治疗点的潜力.
主要方法:
- 对乳腺癌中MALAT1研究的文献综述.
- 分析MALAT1的分子机制,包括基因表达调制和信号通路的影响.
- 对有关MALAT1的预后和诊断价值的临床数据的检查.
主要成果:
- 马拉特1对BC的进展有显著的贡献,包括入侵,转移和扩散.
- 它调节基因表达,并与各种分子伙伴相互作用.
- 马拉特1与抗癌疗法的耐药性有关.
- 临床研究表明,MALAT1作为预后和诊断生物标志物的实用性.
结论:
- 马拉特1是乳腺癌发病的关键调节者,其作用超越了基因组功能.
- 它在治疗耐药性和转移中的作用提供了重要的治疗机会.
- 对MALAT1分子相互作用的进一步研究对于开发BC精准医学策略至关重要.
更多相关视频
11:13Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment
Published on: June 9, 2023
1.5K
10:32Combined Use of Tail Vein Metastasis Assays and Real-Time In Vivo Imaging to Quantify Breast Cancer Metastatic Colonization and Burden in the Lungs
Published on: December 19, 2019
10.8K
相关概念视频
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Tumor Progression
6.3K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.3K
lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
Abnormal Proliferation
4.5K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.5K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
