自由与保守氧化在重症COVID-19患者的比较影响:一项回顾性研究
Deepak Singla1, Priya Tk2, Anirban B Adhikary1
1Anesthesiology and Critical Care, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
这项研究发现,氧气 (PaO2) 的高或低部分压力都没有显著影响2019年冠状病毒病 (COVID-19) 患者的结果. 在这组患者中,氧气治疗的目标并没有改变死亡率或器官衰竭.
科学领域:
- 关键护理医学 关键护理医学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 对于2019年冠状病毒病 (COVID-19) 患者的氧气 (PaO2) 的最佳部分压力进行了辩论.
- 了解不同氧气水平的影响对于管理严重的呼吸道疾病至关重要.
研究的目的:
- 调查氧气 (PaO2) 的高或低部分压力是否会影响COVID-19患者的临床结果.
- 为了比较高PaO2与低PaO2目标管理的COVID-19患者之间的结果.
主要方法:
- 从2020-2022年对COVID-19患者记录的回顾性分析.
- 根据动脉血气 (ABG) 值在氧化后48小时内将患者分为高PaO2 (80-100 mm Hg) 和低PaO2 (60-80 mm Hg).
- 比较P/F比率,顺序器官衰竭评估 (SOFA) 评分,死亡率,排卵,急性损伤 (AKI) 和格拉斯哥昏迷表 (GCS) 变化.
主要成果:
- 与高PaO2组相比,低PaO2组在基线和48小时表现出明显更高的SOFA得分.
- 两组之间在48小时内SOFA分数的变化没有观察到统计学上显著的差异.
- 在37名患者中,高PaO2组的死亡率为21例,低PaO2组的死亡率为18例.
结论:
- 针对COVID-19患者的低或高动脉氧气水平并没有显著改变临床结果.
- 这些发现表明,目前针对COVID-19的氧气治疗策略可能不需要根据PaO2值进行调整.
- 进一步的研究可能会探索其他影响COVID-19患者结果的生理参数.
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