相关实验视频

Updated: Jun 12, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

在狗的诱导过程中,对普罗波福或阿尔法萨的血液动力学效应进行比较

Diego Sarotti¹, Paolo Franci², Stefano Oricco³

¹Centro Veterinario Fossanese, Cuneo, Italy.

Frontiers in veterinary science

|September 26, 2024

概括

普罗波福和阿尔法萨隆在狗中表现出类似的血液动力学效应. 阿尔法萨隆通过在诱导过程中增加心率来更好地维持平均动脉压和心脏输出.

科学领域:

兽医麻醉的比较方法
狗狗的心血管生理学
麻醉剂的药理学麻醉剂的药理学

背景情况:

普罗波是兽医中常见的诱导剂.
阿尔法萨是一种替代性神经活性类固醇麻醉剂.
在麻醉诱导过程中,血液动力学稳定性至关重要.

研究的目的:

为了比较propofol与alfaxalone在狗中麻醉诱导的血液动力学效应.
为了评估心率的变化,平均动脉压和心脏输出.
评估诱导期间低血压的发生率.

主要方法:

随机前性临床研究涉及31只健康的狗.
狗接受了acepromazine和美沙前期治疗.
诱导用普罗波 (5毫克/千克) 或阿尔法萨 (2毫克/千克),然后进行维护输液. 血液动力学参数 (HR,MAP,VTI) 通过心声回声测量.

主要成果:

普罗波导致了平均动脉压 (MAP) 的暂时下降.
阿尔法萨隆诱导与心率 (HR) 的显著增加有关.
总体而言,在MAP,HR或心脏输出 (VTI*HR) 中没有发现显著的群体间差异,但阿尔法萨隆显示出更好的MAP保存趋势.

结论:

普罗波福和阿尔法萨在健康,预先治疗的狗中产生了可比的整体血液动力学变化.
在诱导期间,阿尔法萨在维持MAP和心脏输出方面可能会提供轻微的优势.
进一步的研究可能会在更高风险的狗患者中探索阿尔法萨隆.

关键词:

阿尔法沙龙是一种阿尔法沙龙.麻醉是一种麻醉.狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗狗血液动力学变化变化普罗波福尔 (Propofol) 是一种

更多相关视频

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Recording Brain Electromagnetic Activity During the Administration of the Gaseous Anesthetic Agents Xenon and Nitrous Oxide in Healthy Volunteers

Published on: January 13, 2018

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Optogenetic Activation of Afferent Pathways in Brain Slices and Modulation of Responses by Volatile Anesthetics

Published on: July 23, 2020

相关概念视频

Parenteral Anesthetics: Overview

Parenteral Anesthetics: Overview

Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.

Stages of General Anesthesia

Stages of General Anesthesia

Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...

Inhalational Anesthetics: Overview

Inhalational Anesthetics: Overview

Inhalation anesthetics are drugs that induce general anesthesia upon inhalation. They work by increasing the sensitivity of GABAA receptors or inhibiting NMDA receptors, leading to a decrease in central nervous system activity. The depth of anesthesia can be rapidly adjusted by changing the concentration of the inhaled gas. Some common examples of inhalational anesthetics include volatile liquids like isoflurane, desflurane, sevoflurane and gases like xenon and nitrous oxide. Isoflurane, a...