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针对局部晚期前列腺癌的多模式治疗后的长期瘤结果

Fiorella L Roldan¹, Ugo Giovanni Falagario^2,3, Mats Olsson²

¹Servei d'Urologia, Hospital Clínic de Barcelona Barcelona Spain.

|September 26, 2024

概括

局部晚期前列腺癌 (LAPC) 的治疗方法各不相同,手术对特定患者有潜在的益处. 结果分析揭示了基于瘤阶段和治疗方法的生存差异.

科学领域:

在瘤学瘤学.
泌尿器科泌尿器科泌尿器科泌尿器科
手术瘤学手术瘤学

背景情况:

局部晚期前列腺癌 (LAPC) 是一个复杂的治疗挑战.
了解治疗模式和长期结果对于优化患者护理至关重要.

研究的目的:

评估LAPC (cT3-4,M0) 的治疗模式.
评估LAPC患者的长期瘤结果.
为了分析cT4前列腺癌的彻底手术的结果.

主要方法:

来自斯德哥尔摩的LAPC患者 (cT3-4,M0) 的基于人口的研究 (2003-2019).
对治疗方式的分析:激进前列腺切除术,放射治疗+雄激素剥夺疗法 (ADT) 和单独使用ADT.
对于死亡率预测因素的考克斯回归;对于激进手术小组报告的生存率和并发症率.

主要成果:

包括2921名LAPC患者;9%的急性前列腺切除,51%的RT+ADT,40%的ADT.
10年生存率:76% (RP),47% (RT+ADT) 和23% (ADT) 在10年生存率上.
cT4患者的生存率比cT3患者差. 对于cT4的彻底手术,5年BPFS,CSS,OS率分别为39.6%,68.8%,63.8%,其中33.3%经历了Clavien-Dindo等级III/IV并发症.

结论:

包括激进的骨盆外科手术在内的多学科管理对于选定的LAPC患者可能是有效的.
这种方法可以实现局部瘤控制与可接受的发病率.
对最佳的外科候选人和技术进行进一步的研究是有必要的.

关键词:

癌症特异性生存率癌症特异性生存率细胞静脉静脉切除术 (cystoprostatectomy) 是一种切除术.局部晚期的前列腺癌.激进的盆腔外科手术是什么辐射疗法辐射疗法

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