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Updated: Jul 17, 2026

Use of a Hanging-weight System for Liver Ischemia in Mice
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在肝缺血-再输血损伤中的谷氨胺合成酶表达的动力学:对治疗干预的含义

Zhi-Hao Huang1, Meng-Qi Dong1, Feng-Yong Liu2

  • 1State Key Laboratory of Organ Failure Research, Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.

World journal of hepatology
|September 26, 2024
PubMed
概括

在肝脏组织中肝脏缺血-再输损伤 (IRI) 后,氨酸合成酶 (GS) 表达显著下降. 这表明GS可能作为肝损伤的生物标志物和治疗点.

关键词:
中心静脉 中心静脉谷氨胺合成酶的使用肝脏缺血-再输血 肝脏缺血-再输血伤害修复 伤害修复肝脏 肝脏 肝脏 肝脏

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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug binding...