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Updated: Jun 12, 2025

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过去和现在之间的NSAIDs;朝着理想的COX-2抑制剂的漫长旅程

Nadia A Khalil1, Eman M Ahmed1, Toka Tharwat1

  • 1Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Cairo University 33 Kasr El-Aini Street Cairo 11562 Egypt zeinab.mahmoud@pharma.cu.edu.eg.

RSC advances
|September 26, 2024
PubMed
概括

非类固醇抗炎药物 (NSAIDs) 通过抑制循环氧化酶 (COX) 酶来缓解疼痛. 虽然选择性COX-2抑制剂可以降低胃肠道风险,但它们对心血管的影响在药物开发中需要仔细考虑.

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The gastric mucosa produces prostaglandins E2 (PGE2) and prostacyclin (PGI2), crucial in maintaining gastric health. They exert cytoprotective effects, including increasing bicarbonate secretion, releasing protective mucin, reducing gastric acid output, and preventing harmful vasoconstriction. These effects are mediated through various receptors, such as EP1, EP2, EP3, and EP4.
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