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相关概念视频

Proteomics01:33

Proteomics

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A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
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相关实验视频

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Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
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人类蛋白质组大小作为技术发展的功能.

E V Sarygina1, A S Kozlova1, E A Ponomarenko1

  • 1Institute of Biomedical Chemistry, Moscow, Russia.

Biomeditsinskaia khimiia
|September 26, 2024
PubMed
概括
此摘要是机器生成的。

人类蛋白质组已经显著扩大,估计现在由于翻译后修改 (PTM) 和替代拼接 (AS) 导致的5000万至12500万种蛋白质形式. 这代表了8年来已识别的蛋白质变体增加了20倍.

关键词:
替代性拼接是一种替代性的拼接.在 neXtProt 里面,你会看到neXtProt.翻译后的修改 翻译后的修改蛋白质形式的蛋白质蛋白质组学 蛋白质组学单个氨基酸的替代物

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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

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JUMPn: A Streamlined Application for Protein Co-Expression Clustering and Network Analysis in Proteomics
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Last Updated: Jun 12, 2025

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科学领域:

  • 蛋白质组学是指蛋白质组学.
  • 生物信息学是一种生物信息学.
  • 分子生物学分子生物学

背景情况:

  • 2016年提出的数学模型预测了人类蛋白质的数量.
  • 自2016年以来,neXtProt数据库中蛋白质形式信息的变化分析.
  • 研究后翻译修改 (PTM),替代拼接 (AS) 和单氨基酸多态 (SAP) 对蛋白质组复杂性的影响.

研究的目的:

  • 在数据库中更新已识别的蛋白形状的状态.
  • 为了识别蛋白质形式记录数量的趋势.
  • 为了将当前的蛋白质组大小估计与早期预测进行比较.

主要方法:

  • 对neXtProt数据库信息的回顾性分析.
  • 将2016年数据与当前信息资源进行比较.
  • 蛋白质组变化的相关性与蛋白质修饰分析的新实验和生物信息学方法.

主要成果:

  • 人类蛋白质的估计数量急剧增加,从5000万增加到1.25亿.
  • 这种扩张归因于替代拼接,蛋白质层面的单核酸多态以及PTMs.
  • 在过去的八年里,人类蛋白质组的大小可能增加了20倍以上.

结论:

  • 现代实验方法和生物信息学分析揭示了一个极度扩大的人类蛋白质组.
  • 人类蛋白质组的复杂性被旧的模型大大低估了.
  • 持续更新数据库和先进的分析技术对于理解蛋白质组动态至关重要.