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Updated: Jun 12, 2025

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
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A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

Published on: August 29, 2020

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开发一种基于分子的Lin28降解剂,以调节细胞增殖和干性

Minha Lee1, Wan Gi Byun1, Sumin Son1

  • 1CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea. sbpark@snu.ac.kr.

Chemical communications (Cambridge, England)
|September 26, 2024
PubMed
概括

研究人员开发了SB1349,一种针对Lin28的分子降解剂,以恢复let-7微RNA (miRNA) 水平. 这种方法降低了瘤基因的调节,促进了细胞分化,显示了与干性相关的疾病的治疗潜力.

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