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核和杏仁体之间的功能连接是青春期避免学习的基础:对发育心理病理学的影响

Benjamin M Rosenberg¹, João F Guassi Moreira¹, Adriana S Méndez Leal¹

¹Department of Psychology, University of California, Los Angeles (UCLA), Los Angeles, CA, USA.

Development and psychopathology

|September 26, 2024

概括

青少年大脑中,在逃离威胁时,核结合体 (NAcc) 和杏仁体之间的连接性增加. 较高的内化症状与安全期间更强的NAcc-杏仁体连接相关,这表明威胁歧视受损.

科学领域:

神经科学是一个神经科学.
发展心理学发展心理学
青少年精神病理学青少年精神病理学

背景情况:

青春期伴随着越来越多的接近行为,伴随着越来越多的内化症状,以避免为特征.
在奖励处理过程中至关重要的核 (NAcc) 也可能在青少年威胁机制和精神病理学中发挥作用.

研究的目的:

调查在青少年中厌恶性学习期间NAcc和杏仁体之间的功能连接.
检查在威胁和安全提示期间内化症状和NAcc-杏仁体连接之间的关系.

主要方法:

47名典型发育的青少年在厌恶性学习任务期间接受了功能磁共振成像 (fMRI).
参与者看到了与可逃脱的厌恶声音,非厌恶刺激或中性刺激配对的线索.
用家长报告的尺度来评估内化症状.

主要成果:

对于可逃脱的厌恶刺激 (CS+r),NAcc-杏仁体的功能连接性显著增加.
具有较高内化症状的青少年对安全线索 (CS-) 显示出更大的积极NAcc-杏仁体连接性.

结论:

青少年在逃离威胁时表现出高度的NAcc-桃体连接性.
在青少年内化症状的安全期间,NAcc-桃体连接性升高可能表明难以区分安全与威胁.

关键词:

青少年时期青春期焦虑是一种焦虑.抑郁抑郁症抑郁症抑郁症是一种功能连接性的功能连接性学习威胁学习威胁

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