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Updated: Jun 12, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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RUNX1::MIR99AHG 在急性髓性白血病中的奇米拉

Kristin Andersen1, Geir E Tjønnfjord2,3, L Frode Ramslien4

  • 1Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, the Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

Genes, chromosomes & cancer
|September 26, 2024
PubMed
概括

这项研究报告了急性髓性白血病 (AML) 中罕见的RUNX1::MIR99AHG融合,这一发现仅在三个病例中发现. 该患者还出现了FLT3异常,这种异常在类似的AML病例中很常见.

关键词:
转录因子1 (RUNX1) 是RUNX家族的一种转录因子.RUNX1::MIR99AHG 迷幻的世界急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.在第二十一章中,我说了很多话.mir‐99a‐let‐7c 集群宿主基因 (MIR99AHG) 的研究结果

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