自我报告的听力损失与更快的认知和功能衰退有关,但在ADNI队列中没有诊断转换
Alyssa A Miller1,2, Emily S Sharp1,3, Selena Wang4,5
1Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut, USA.
Alzheimer's & dementia : the journal of the Alzheimer's Association
|September 26, 2024
概括
听力损失加快了老年人的认知和功能衰退. 然而,它不会增加发展为痴呆症或其他认知障碍的风险.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 听力损失是认知障碍和痴呆症的一个显著可修改的风险因素.
- 之前关于听力损失与认知的联系的研究已经产生了不一致的结果.
- 阿尔茨海默病神经成像计划 (ADNI) 为研究这种关系提供了有价值的队列.
研究的目的:
- 检查自我报告的听力损失与认知/功能表现之间的纵向关联.
- 为了确定听力损失是否会增加进展到更严重认知障碍的风险.
- 分析ADNI研究中认知正常 (CN) 和轻度认知障碍 (MCI) 参与者的数据.
主要方法:
- 对自我报告的听力损失进行纵向分析.
- 使用修改后的临床前阿尔茨海默氏症认知复合物的认知衰退的评估.
- 使用功能活动问卷 (FAQ) 评估功能衰退.
- 包括ADNI队列中的695名CN和941名MCI参与者.
主要成果:
- 听力损失的参与者表现出明显更快的认知能力下降率 (CN组).
- 听力损失的CN和MCI参与者都经历了功能衰退的明显更快的速度.
- 在CN或MCI组中,听力损失并没有显著增加进展到更受损诊断的风险.
结论:
- 自我报告的听力损失在纵向上与加速的认知和功能衰退有关.
- 虽然听力损失会影响认知和功能,但在这个群体中,听力损失并不是转化为痴呆症或MCI的预测因素.
- 这些发现强调了解决听力损失作为人口老龄化的可修改因素的重要性.
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