阻塞性睡眠呼吸暂停与非酒精性脂肪胰腺疾病独立相关
Jiaojiao Lin1, Han Wang1, Xiaoyang Chen2
1Department of Ultrasonography, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.
Scandinavian journal of gastroenterology
|September 26, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 与非酒精性脂肪胰腺疾病 (NAFPD) 的更高患病率有关. 增加的呼吸暂停-呼吸暂停指数 (AHI),BMI和高血压是OSA患者NAFPD的独立风险因素.
科学领域:
- 胃肠病学和肝病学
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 非酒精性脂肪胰腺疾病 (NAFPD) 是一个新兴的健康问题.
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍存在的睡眠障碍,与各种代谢并发症有关.
研究的目的:
- 在被诊断为OSA的患者中调查NAFPD的患病率.
- 分析OSA严重程度与NAFPD之间的相关性.
- 在OSA群体中确定NAFPD的独立风险因素.
主要方法:
- 招募了210名参与者的队列,分为OSA和对照组.
- 用于诊断的多睡眠图和修改的腹部超声波.
- 进行二进制物流回归分析以确定风险因素.
主要成果:
- 与对照组相比,OSA组的NAFPD,体重和BMI患病率明显高 (p <0.05).
- 在OSA组中的NAFPD患者显示高血压,代谢相关脂肪性肝病 (MASLD) 的患病率更高,睡眠呼吸暂停的严重程度更高 (p <0.05).
- 呼吸暂停-呼吸暂停指数 (AHI) 每个单位的增加与NAFPD风险增加4.4%有关,独立于BMI和高血压.
结论:
- 在患有OSA的患者中,NAFPD更为普遍.
- 在OSA中,慢性间歇性缺氧与胰腺脂肪透密切相关.
- 呼吸暂停-呼吸暂停指数 (AHI),BMI和高血压被确定为NAFPD的独立风险因素.
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