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用抗甲状腺药物预测胰腺炎风险的机器学习:全国一项回顾性观察性研究
Muhammed Kızılgül1, Talip Yigit2, Naim Ata3
1Etlik City Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
The Journal of clinical endocrinology and metabolism
|September 26, 2024
概括
甲 (PTU) 增加了甲状腺炎患者的急性胰腺炎 (AP) 风险,而propranolol则降低了这一风险. 在这项大型人群研究中,甲马 (MMI) 与AP风险没有显著的关联.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 越来越多的证据表明,使用甲基马 (MMI) 会增加急性胰腺炎 (AP) 的风险.
- 甲状腺功能障碍的治疗需要对AP进行仔细的风险效益评估.
- 需要基于人口的数据来澄清与药物相关的AP风险.
研究的目的:
- 为了调查甲状腺功能高的药物 (MMI,PTU,propranolol) 和AP诊断之间的关联.
- 量化与特定甲状腺功能增强治疗相关的AP风险.
- 为了告知临床实践关于高甲状腺症中药物诱导的AP.
主要方法:
- 利用了超过8500万条记录 (2017-2022) 的基于人口的数据集.
- 使用ICD-10代码识别甲状腺功能过高的患者和那些发展AP的患者.
- 采用考克斯回归模型与测试训练机器学习技术进行分析.
主要成果:
- 检查了1,329,934名甲状腺功能过高患者;10,815名 (0.81%) 患有AP.
- 甲 (PTU) 使用增加了10%的AP概率 (p=0.0009).
- 兰醇使用AP概率降低了5% (p=0.032),预测成功率为52.2%.
结论:
- 使用PTU与AP风险增加有关;使用propranolol与风险降低有关.
- 在MMI使用和AP风险之间没有发现统计学意义上的关联.
- 临床医生应该意识到与药物相关的AP风险,以便及时诊断和治疗.
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