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母婴睡眠时间短暂与子女神经发育迟缓的关联:前性队列研究
Lei Zhang1,2,3,4, Hai-Xia Wang1,2,3,4, Wen-Xiang Li1
1Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China.
The Journal of clinical endocrinology and metabolism
|September 26, 2024
概括
怀孕期间睡眠时间短暂与男性后代的神经发育延迟有关. 这种关联可能部分归因于较高的带C水平,影响了儿童的发育.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 发展心理学 发展心理学
背景情况:
- 怀孕期间睡眠时间短 (SSD) 是对母亲健康和儿童发育日益关注的问题.
- 了解母亲睡眠对后代神经发育的影响,对于制定有效的怀孕指南至关重要.
研究的目的:
- 调查怀孕期间母亲睡眠时间短 (SSD) 与后代神经发育延迟之间的联系.
- 探索胎儿葡萄糖代谢的潜在作用,由带血C-水平表明,在调解这种关系.
主要方法:
- 在合肥的母婴健康队列中,对7059对母婴对进行了队列研究.
- 使用匹兹堡睡眠质量指数评估母亲的睡眠;使用丹佛发育查测试-II和吉塞尔发育诊断尺度评估后代的神经发育.
- 考克斯比例危险回归和调解分析被用来分析数据.
主要成果:
- 在怀孕中期的孕产妇SSD与男性后代神经发育迟缓的风险增加显著相关 (aHR2.05).
- 较高的带血血清C-水平与后代的神经发育延迟 (RR 0.04) 有积极的关系.
- 带血C-水平介导了大约11.05%的母亲SSD和后代神经发育延迟之间的关联.
结论:
- 怀孕期间母亲睡眠时间短暂与子女神经发育迟缓的发病率增加有关,性别差异显著.
- 带C水平升高可能部分调解母亲睡眠时间和儿童神经发育结果之间的关系.
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