医院工作人员的耐药细菌殖民:流行病学监测和打字研究
Tina Badinski1, Salome N Seiffert2, Fabian Grässli1
1Division of Infectious Diseases, Infection Prevention and Travel Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland.
Antimicrobial agents and chemotherapy
|September 26, 2024
概括
医疗保健工作者 (HCWs) 显示,肠道殖民的患病率为5.4%,其中包括扩展谱β-乳糖酶产生肠道细菌 (ESBL-E). 旅行和寿司消费等非职业因素与ESBL-E殖民有关,而不是工作暴露.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 流行病学 流行病学
背景情况:
- 用ESBL-E,CPE和VRE等多耐药生物体 (MDRO) 殖民肠道是一个日益严重的公共卫生问题.
- 医疗保健工作者 (HCW) 可以在医疗保健机构内充当MDRO传播的储存器和潜在载体.
- 了解HCW中的殖民流行率和风险因素对于感染控制和抗生素管理至关重要.
研究的目的:
- 在瑞士东北部的HCW中确定ESBL-E,CPE和VRE肠道殖民的流行率.
- 使用全基因组测序 (WGS) 调查检测到的MDROs的分子流行病学.
- 确定与高温工厂中MDRO殖民相关的职业和非职业风险因素.
主要方法:
- 一项涉及来自瑞士东北部14所机构的1209名高职工的横截面研究.
- 收集了直肠拭子,并对ESBL-E,CPE和VRE进行了查.
- 全基因组测序 (WGS) 进行在分离物上;逻辑回归分析了风险因素.
主要成果:
- ESBL-E殖民的流行率为5.4%,CPE为0.1%;没有检测到VRE.
- 对ESBL-E殖民的重大风险因素包括非欧洲族裔,前往高风险国家,全身使用抗生素,抗生素眼滴和每月寿司消费.
- 酒精消费与ESBL-E殖民有负面关联;没有相关的职业因素.
结论:
- 职业暴露与HCW中的ESBL-E殖民并不相关.
- 非欧洲族裔,国际旅行,使用抗生素,抗生素眼滴和寿司消费是ESBL-E殖民的潜在风险因素.
- 需要进一步的研究来阐明寿司消费和抗生素眼滴在HCW中MDRO殖民中的作用.
关键词:
这就是ESBL.抗生素耐药性 抗生素耐药性殖民化 殖民化的殖民化流行病学流行病学医疗保健工作者 医疗保健工作者职业 职业 职业是什么患病率的流行情况.有关风险因素的风险因素.寿司寿司寿司 寿司寿司是什么意思更多相关视频
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