高血清循环的无细胞线粒体DNA在肌缩性侧面硬化症中升高
Jieyu Li1, Chao Gao1, Qingqing Wang1
1Department of Neurology, Peking University First Hospital, Beijing, China.
European journal of neurology
|September 26, 2024
概括
在肌缩侧面硬化症 (ALS) 患者中发现了循环无细胞线粒体DNA (ccf-mtDNA) 的升高水平,表明与炎症有关. 这些ccf-mtDNA水平可以作为ALS进展的生物标志物,特别是在具有SOD1突变的个体中.
科学领域:
- 神经免疫学 神经免疫学
- 线粒体生物学 线粒体生物学
- 神经退行性疾病 神经退行性疾病
背景情况:
- 炎症在肌缩侧面硬化症 (ALS) 中起着重要作用.
- 循环的无细胞线粒体DNA (ccf-mtDNA) 与免疫激活和神经退行有关.
研究的目的:
- 在ALS患者中量化血清ccf-mtDNA水平.
- 探索ccf-mtDNA与ALS疾病特征之间的关联.
主要方法:
- 在62名ALS患者和46名健康对照人群中测量了血清ccf-mtDNA水平.
- 在26名ALS患者中评估了互白素-6 (IL-6) 水平.
- 分析了ccf-mtDNA,疾病进展 (ΔFS,ALSFRS-R) 和IL-6之间的相关性.
主要成果:
- 与对照组相比,ALS患者的血清ccf-mtDNA水平显著更高.
- 升高的ccf-mtDNA在患有超氧化解突变酶1 (SOD1) 突变的ALS患者中最为明显.
- 血清ccf-mtDNA水平与ALS进展率 (ΔFS) 有负相关性,与IL-6水平有正相关性.
结论:
- 在ALS患者的血清ccf-mtDNA增加表明在炎症途径和疾病发病过程中发挥了作用.
- ccf-mtDNA可以作为监测ALS进展的潜在生物标志物,特别是在SOD1突变载体中.
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