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在新加坡的COVID-19疫苗接种后的过敏反应
Li Fung Peck1, Wang Woon Poh1, Adena Theen Lim1
1Vigilance and Compliance Branch, Health Products Regulation Group, Health Sciences Authority, Singapore.
Singapore medical journal
|September 26, 2024
概括
接种COVID-19疫苗后的过敏反应很少见,大多数病例发生在mRNA疫苗后不久. 这一审查指导了疫苗接种策略,并增强了对异种疫苗接种安全性的理解.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 公共卫生 公共卫生
背景情况:
- 在新加坡,在COVID-19疫苗接种后,被确定过敏症是严重的不良事件.
- 对mRNA疫苗过敏的个体提供了非mRNA替代品.
- 这项研究检查了过敏反应报告和异种COVID-19疫苗接种病例.
研究的目的:
- 描述健康科学局 (HSA) 收到的过敏反应报告.
- 审查接受异种COVID-19疫苗接种的个体的结果.
- 评估安全性并为疫苗接种策略提供信息.
主要方法:
- 过敏反应报告 (直到2022年7月) 根据布莱顿协作标准进行裁决.
- 专家小组对病例的审查,包括那些有异种疫苗接种的病例.
- 在接下来的疫苗剂量后对反应的分析.
主要成果:
- 审查了112例过敏症病例;大多数是女性,成年人和有过敏史的人.
- 大多数过敏反应事件 (71%) 发生在接种疫苗后30分钟内.
- 对于mRNA疫苗的发病率很低,在全球范围内是可比的;对于非mRNA疫苗的发病率更高,可能是由于选择偏差. 异种疫苗接种显示出各种反应.
结论:
- 过敏反应是一种罕见但严重的不良事件,可以通过及时的医疗护理来管理.
- 案例审查为接种策略和异种疫苗接种的安全数据提供了信息.
- 及时干预是缓解过敏反应结果的关键.
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