炎症负担指数,前列腺癌和中年和老年人死亡率之间的关联
Junpeng Deng1,2, Jingqi Hua2, Tengyue Zeng2
1Department of Urology, The First Affiliated Hospital of Soochow University, No.899, Pinghai Road, Gusu District, Suzhou, Jiangsu, 215006, China.
炎症负担指数 (IBI) 预测40岁以上男性的死亡风险. 较高的IBI与高的前列腺癌风险相结合,显著增加死亡率,超过单个炎症标志物.
科学领域:
- 在瘤学瘤学.
- 炎症研究 炎症研究
- 生物标志物发现发现
背景情况:
- 炎症是前列腺癌 (PCa) 进展和死亡率的关键驱动因素.
- 评估40岁以上男性的死亡风险需要了解炎症标志物.
- 炎症负担指数 (IBI) 是系统性炎症的复合标志物.
研究的目的:
- 评估炎症负担指数 (IBI) 对40岁及以上男性死亡风险的预测能力.
- 确定IBI及其组件是否可以预测高前列腺癌风险的个体的死亡率.
主要方法:
- 来自NHANES 2001-2010数据集的7344名参与者的分析.
- 高PCa风险的定义:%fPSA>25%和tPSA<4.0 ng/mL.
- 使用考克斯回归,物流回归,ROC曲线分析和随机生存森林 (RSF) 模型.
主要成果:
- 增加的IBI水平与增加的全因 (HR 1.08) 和癌症死亡率 (HR 1.11) 有显著的相关性.
- 高风险的PCa病例显示死亡率高:所有原因 (HR 1.35) 和癌症 (HR 1.65).
- 对于联合高IBI和高PCa风险 (所有原因HR 1.49,癌症HR 1.76) 观察到的协同死亡影响. IBI表现出优越的预测价值,而不是单个标记.
结论:
- 增加IBI和高PCa风险协同增加40岁以上男性的死亡风险.
- IBI比单个炎症标志物更有效地预测死亡率.
- 在高风险PCa人群中,IBI显示为预后生物标志物,用于评估高风险PCa人群的死亡风险.
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