评估T淋巴细胞在恶性和良性肺溢液中对PD-1和互白素-10受体的表达
B Mosleh1, B Hammer2,3, A El-Gazzar2
1Department of Thoracic Surgery, Comprehensive Cancer Center Vienna, Medical University of Vienna, Vienna, Austria.
Clinical and experimental medicine
|September 26, 2024
概括
癌症中的免疫逃避涉及PD-1/PD-L1和IL-10/IL-10R通路. 这项研究发现,恶性多流液中T细胞的PD-1和IL-10R表达率较低,这表明瘤有着独特的微环境.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 编程细胞死亡蛋白-1 (PD-1) /PD-L1和白蛋白-10 (IL-10) /IL-10受体 (IL-10R) 相互作用对于瘤免疫逃避至关重要.
- 之前的研究已经探索了癌症患者的肺溢液 (PE) 中T淋巴细胞上的PD-1表达,但恶性PE (MPE) 和良性PE (BPE) 之间的比较有限.
研究的目的:
- 研究和比较MPE与BPE中T淋巴细胞上PD-1和IL-10R的表达.
- 阐明PD-1和IL-10R在瘤微环境中的作用.
主要方法:
- 这是一项前性研究,涉及51名患有恶性或良性PE的患者.
- 在细胞学样本中使用流细胞计对PD-1和IL-10R的T细胞表达的分析.
- 将患者分为三组:MPE,恶性疾病中的BPE和良性疾病中的BPE.
主要成果:
- 与良性流 (BPE) 相比,恶性流 (MPE) 在CD4+细胞上显示了PD-1+ T淋巴细胞的比例明显较低 (40.1%对56.3%).
- 与BPE组相比,MPE表现出PD-1+IL-10R+CD8+T细胞的显著较低表达 (9.6%) 和PD-1-IL-10R-CD8+T细胞的显著较高表达 (43.7%).
- 这些差异表明MPE中由瘤细胞驱动的独特的微环境.
结论:
- 与BPE相比,MPE中表达PD-1和IL-10R的T细胞的频率明显较低.
- 这些发现凸显了PD-1和IL-10R途径在恶性外泄的免疫动态中的潜在参与.
- 这项研究表明,MPE中存在一种独特的瘤微环境,影响T细胞免疫反应.
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