吸烟与部骨折风险之间的性别差异
Yilun Tang1, Yan Xu2, Jinhui Song3
1Department of Orthopedics, The Second Affiliated Hospital of Xi'an Jiaotong University, No. 157, West 5th Road, Xi'an, 710103, China. a_lun1111@163.com.
Journal of bone and mineral metabolism
|September 26, 2024
概括
目前的吸烟显著增加了关节骨折的风险更多的男性比女性. 这种性别风险差异在前吸烟者中没有观察到,这表明吸烟史对骨健康的明显影响.
科学领域:
- 流行病学 流行病学
- 骨健康 骨健康 骨健康
- 老年学是一门学科.
背景情况:
- 吸烟是骨质疏松症和关节骨折的已知危险因素.
- 以前的研究表明,吸烟对骨健康的影响可能存在性别差异,但证据仍然不确.
研究的目的:
- 量化评估吸烟与关节骨折风险之间的关联,特别研究性别差异.
- 综合现有证据,使用元分析方法,对男性与女性风险比率进行可靠估计.
主要方法:
- 在PubMed,Embase和Cochrane图书馆数据库中进行了系统的文献搜索,以寻找潜在的队列研究.
- 来自11项研究的数据,包括2,689,620人,使用随机效应模型来评估性别特异性风险进行了分析.
- 相对风险比率 (RRR) 的计算是为了比较男性和女性吸烟者之间的关节骨折风险.
主要成果:
- 与女性相比,目前的吸烟与男性部骨折相对风险 (RRR) 的比率显著更高 (RRR: 1.10; 95% CI: 1.001.20; P=0.047).
- 在与前吸烟相关的关节骨折风险方面没有发现显著的性别差异 (RRR:0.98;95% CI:0.881.10;P=0.759).
结论:
- 与目前的吸烟相关的部骨折风险增加在男性中比女性更为明显.
- 过去吸烟对关节骨折风险的影响在男女之间似乎没有差异.
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