确定预测乳腺切除术后边际状况的因素
Matthew R Woeste1, Kevin Jacob1, Mackenzie Shindorf1
1The Hiram C. Polk Jr. MD Department of Surgery, University of Louisville School of Medicine, Louisville, KY, USA.
Annals of surgical oncology
|September 26, 2024
概括
乳腺切除术后的积极边际增加了乳腺癌复发风险. 诸如年龄,BMI和新辅助化疗等因素可以预测边缘状态,有助于患者咨询.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 乳腺癌研究研究 乳腺癌研究
背景情况:
- 乳腺切除术后的正边缘增加了乳腺癌复发风险,需要进一步治疗.
- 识别边缘状态的预测因素对于优化外科手术结果至关重要.
研究的目的:
- 为了确定与乳腺切除术后的积极或接近边缘相关的临床病理因素.
- 提供有关乳房切除术结果的外科规划和患者咨询信息.
主要方法:
- 对938名患有Tis-T3乳腺癌的女性进行了乳腺切除术 (2014-2020年) 的回顾性分析.
- 患者之间临床病理学数据的比较,负边缘 (>1毫米) 和接近 (≤1毫米) 或正边缘.
主要成果:
- 15%的患者有接近或积极的边缘;其中26%需要重新切割,24%显示残留癌症.
- 阳性边缘风险降低与年龄增长,BMI升高和新辅助化疗相关.
- 增加的风险与较低的内象限瘤,多焦点性疾病,立即重建和高瘤与乳房体积比率有关.
结论:
- 年龄,BMI,瘤位置,多焦点性,新辅助化疗,立即重建和瘤与乳腺体积比是乳腺切除边缘状态的独立预测因素.
- 这些因素应指导进行乳房切除术的患者进行手术前咨询.
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