口腔微生物组和随后的头部和部状细胞癌的风险
Soyoung Kwak1,2, Chan Wang1,2, Mykhaylo Usyk1,2
1Department of Population Health, NYU Grossman School of Medicine, New York, New York.
JAMA oncology
|September 26, 2024
概括
口腔细菌,而不是真菌,与头部和部状细胞癌 (HNSCC) 风险有关. 特定的细菌物种和复合物增加HNSCC的发展,帮助个性化预防策略.
科学领域:
- 微生物学 微生物学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 口腔微生物组在头部和部状细胞癌 (HNSCC) 中的作用正在调查中,来自小型研究的证据有限.
- 现有的研究主要依赖于细菌16S安普利康测序.
研究的目的:
- 确定口腔细菌和真菌微生物组是否与随后发展HNSCC的风险有关.
- 为了确定HNSCC的特定微生物风险因素.
主要方法:
- 在三个大型流行病学队列中进行了前性嵌套病例控制研究.
- 用细菌的全基因组猎枪测序和真菌的内部转录间距测序来分析口服样本.
- 通过组合分析和后勤回归来评估相关性,并开发出微生物风险评分.
主要成果:
- 在整体口腔微生物群多样性和HNSCC风险之间没有发现任何关联.
- 包括Prevotella salivae和Streptococcus sanguinis在内的13种口腔细菌物种与HNSCC发展有差异性关联.
- 红色/色牙周病原体复合体与HNSCC风险存在中度关联,基于22种细菌的微生物风险评分将HNSCC风险增加50%.
结论:
- 口腔细菌,但不是真菌,是令人信服的连接作为HNSCC发展的危险因素.
- 鉴定的细菌和复合体可以为个性化的HNSCC预防策略做出贡献.
- 进一步的研究可以将这些微生物发现与其他风险因素进行整合,以改善风险分层.
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