在急性缺血性中风患者中,tongxinluo和功能结果:一项随机临床试验
Yi Dong1, Kaifu Jiang2, Zhenguang Li3
1Department of Neurology, Huashan Hospital Fudan University, Shanghai, China.
JAMA network open
|September 26, 2024
概括
在急性缺血性中风患者中,tongxinluo改善了功能结果. 与安慰剂相比,这种传统中医改善了恢复,提供了一个有前途的神经保护治疗选择.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 传统中国医药 传统中国医药
背景情况:
- 当前神经保护剂对急性缺血性中风 (AIS) 的有效性有限.
- 传统中医药中的tongxinluo显示出潜在的神经保护和抗炎性质.
- 之前的研究表明,Tongxinluo在动物模型和心肌梗塞患者中稳定斑块的有效性.
研究的目的:
- 评估Tongxinluo作为急性缺血性中风 (AIS) 患者辅助治疗的疗效和安全性.
主要方法:
- 一个多中心,随机,双盲,安慰剂对照试验,涉及2007年AIS患者.
- 患者接受Tongxinluo或安慰剂口服,每天三次,持续90天,并接受标准治疗.
- 在90天后,使用修改的兰金尺度 (mRS) 评估了功能性结果.
主要成果:
- 与安慰剂相比,Tongxinluo在90天内显著增加了有利的功能结果 (mRS 0-1),达到65.8%与59.1%相比,或1.33,P=.002).
- 在预先指定的子组中,治疗效果一致.
- 与tongxinluo相关的显著不良事件没有被突出显示,这表明了有利的安全概况.
结论:
- 辅助Tongxinluo治疗改善了急性缺血性中风患者在症状出现后72小时内功能结果.
- 在AIS管理中,tongxinluo代表了一个可行的神经保护选择.
- 建议进行进一步的研究,以探索其对接受血栓溶解和内血管治疗的患者的影响.
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