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在外周动脉疾病中使用CathCam引导的图秒红外激光切除术重血管化

Mohammadmahdi Tahmasebi, Rob Reyes Perez, Andrew Marques

IEEE transactions on bio-medical engineering

|September 26, 2024

概括

与传统方法相比,Picosecond中红外激光 (PIRL) 在外围动脉封闭中显著改善了交叉成功. 最佳的结果是在0.1mm/s的纤维进步速度以最小的组织创伤实现的.

科学领域:

血管外科血管外科
生物医学工程生物医学工程
激光医学是激光医学.

背景情况:

对于外围动脉封闭的内血管再血管化,技术失败率很高 (15-20%).
导线穿越困难是这些故障的主要原因之一.
需要新的技术来提高程序的成功.

研究的目的:

评估Picosecond中红外激光 (PIRL) 系统在促进导线穿越外围动脉封闭的有效性.
为了确定PIRL辅助穿越的最佳参数.
评估PIRL与图像引导导管结合使用的安全性和可行性.

主要方法:

动脉损伤样本被用来测试PIRL系统在不同的功率输出 (500mW,1000mW) 和受控的光纤进步速度.
微计算机断层扫描 (μ-CT) 和组织学分析进行了前和后的消去.
在X射线光镜下,使用PIRL与CathCam可导向导管在X射线光镜下评估可行性.

主要成果:

激光ON显著改善了交叉成功 (95.6%),而不是激光OFF (73.9%) (p<0.05).
使用PIRL (5.5 ± 9.8g与17.2 ± 12.3g相比) 显著降低了最大交叉力 (p << 0.05).
在0.1毫米/秒的纤维速度下观察到最佳性能,产生高成功率和最小的 (小于50微米) 组织创伤.

结论:

皮尔 (PIRL) 斑块切除是一种最少的侵入性技术,可以提高内血管手术的成功率.
确定了0.1mm/s的最佳光纤进步速度,用于PIRL辅助穿越.
与像CathCam这样的图像引导系统集成的PIRL显示了改善内血管再血管化结果的巨大潜力.

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