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破坏作为一个创造性过程:CAD诱导的DNA链断裂促进了巨细胞的分化

Dalal Alsowaida1, Lynn A Megeney2

  • 1Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute and the Departments of Medicine and Cellular and Molecular Medicine, University of Ottawa, Ottawa K1H 8L6, Canada; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Cell reports
|September 26, 2024
PubMed
概括

在巨细胞分化过程中,DNA链断裂是由Drep4驱动的,Drep4是Drosophila caspase激活DNase (CAD) 的同类物. 这种Drep4/CAD活动对于整个差异化过程至关重要.

关键词:
CP: 免疫学 免疫学

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