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Updated: Jun 12, 2025

Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes
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Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

Published on: January 12, 2024

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利用共价性稳定细胞-细胞"诱导的近距离"的三元复合体形成

Karolina Krygier1, Anjalee N Wijetunge1, Arthur Srayeddin1

  • 1Center for Discovery in Cancer Research, Department of Biochemistry and Biomedical Sciences, Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4L8.

ACS chemical biology
|September 26, 2024
PubMed
概括

协同免疫招募剂 (CIRs) 通过形成稳定的三元复合体来增强药物疗效,改善向细胞杀死. 这种方法利用不可逆转的共价键来稳定相互作用,在基于免疫的疗法中优于非共价方法.

关键词:
在 ARM 中,可以使用 ARM.SuFEx SuFEx 是一个亲缘关系电友的电友.亲和关系标签的标签.双功能的分子分子.一个共价的奇默.免疫疗法 免疫疗法诱导的亲近性诱导的亲近性组织前预先组织.三元复合体是一个三元复合体.

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