年轻成年期血压轨迹和晚年心血管事件
Mengying Xia1, Jaejin An2,3, Heidi Fischer2
1Division of General Medicine, Columbia University Irving Medical Center, New York, New York, USA.
American journal of hypertension
|September 26, 2024
概括
在年轻成年期保持低稳定的血压 (BP) 轨迹对于预防晚年心血管疾病 (CVD) 至关重要. 升高升高的血压模式显著增加心脏病,中风和心力衰竭的风险.
科学领域:
- 心脏病学 心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 在生命早期了解长期血压 (BP) 模式是预测未来心血管疾病 (CVD) 风险的关键.
- 在年轻成年期调查BP轨迹,可以了解晚年心血管疾病的发展.
研究的目的:
- 在年轻人中识别不同的血压 (BP) 轨迹组.
- 评估这些BP轨迹与随后的心血管疾病 (CVD) 风险之间的关联.
主要方法:
- 从两个美国队列 (CARDIA,弗雷明汉心脏研究) 的数据汇总.
- 利用潜增长曲线模型来定义BP轨迹 (18-39岁).
- 在40岁以后,使用Cox比例危险模型将轨迹与心血管疾病事件 (心脏病,中风,高血压) 联系起来.
主要成果:
- 在6,579名参与者中,确定了4个不同的缩血压 (SBP) 轨迹组.
- 一个升高增加的SBP轨迹与显著更高的心血管疾病风险有关 (HRs从3.25到8.30不等).
- 高血压轨迹改善了心血管疾病事件的预测模型.
结论:
- 年轻成年期血压升高升高的轨迹是晚年心血管疾病的重要预测因素.
- 在年轻成年期保持低稳定的血压轨迹对于预防心血管疾病至关重要.
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