皮拉津胺使用对老年结核病患者严重不良事件的影响:多中心队列研究
Joon Young Yoon1, Tae-Ok Kim1, Ju Sang Kim2
1Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, South Korea.
PloS one
|September 26, 2024
概括
皮拉津胺 (PZA) 对老年结核病 (TB) 患者是安全的. 这项研究发现PZA没有增加不良事件或治疗中断,这表明它可以安全地纳入老年人结核病治疗方案.
科学领域:
- 老年医学 老年医学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 在老年结核病 (TB) 患者中,由于对药物不良反应的担忧,通常会避免使用PZA.
- 这项研究研究了在接受结核病治疗的老年人中PZA的安全性和有效性.
研究的目的:
- 为了确定PZA的使用是否与老年结核病患者的不良结果有关.
- 评估PZA对严重不良事件 (SAE),药物中断和随访损失 (LTFU) 的影响.
主要方法:
- 对65岁及以上结核病患者的前队列的回顾性分析.
- 2019年7月至2023年6月期间,从韩国共和国的18个机构收集的数据.
- 在接受PZA或不接受PZA治疗的患者中,评估了SAE,药物中断和LTFU的发生率.
主要成果:
- 在91.3%的老年结核病患者中,使用PZA.
- 在接受PZA (89.9%) 的患者中,治疗成功率明显高于未接受PZA (64.7%) 的患者.
- 没有发现PZA是SAE,药物中断或LTFU (OR 0.457,95% CI 0.201-1.041) 的风险因素.
结论:
- 在老年结核病患者中,PZA的使用没有增加SAE,药物中断或LTFU.
- 由于潜在的优势,将PZA纳入老年结核病治疗方案可能是值得建议的.
- 这些发现挑战了目前在这个人口群体中避免PZA的现象.
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