Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Regression Toward the Mean01:52

Regression Toward the Mean

6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Study Designs in Epidemiology01:20

Study Designs in Epidemiology

189
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
189
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

2.6K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.6K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

4.3K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.3K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

341
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
341
Randomized Experiments01:13

Randomized Experiments

6.8K
The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
Simple randomization
Simple...
6.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Leaching kinetics and mechanisms in efficient chlorination leaching of germanium-rich fume dust.

RSC advances·2026
Same author

Chaperone-Mediated Autophagy-Directed Degradation of PI3K in Tumor Cells: Development of Multifunctional Peptide-Drug Conjugates With Enhanced Penetration and Selectivity.

Archiv der Pharmazie·2026
Same author

AI-quantified Myosteatosis at CAC CT for Prediction of Atrial Fibrillation and Heart Failure: The Multi-Ethnic Study of Atherosclerosis.

Radiology. Cardiothoracic imaging·2026
Same author

CD90 mediates gastric cancer immune evasion though regulating IGF2BP2 to stabilize the m6A-CD47/SIRPα axis.

Cancer cell international·2026
Same author

Frustration reduces interpersonal competition through dynamic interpersonal neural synchronization in dyads.

Communications biology·2026
Same author

Hematopoietic stem and progenitor cells derived platelet lysate promotes diabetic wound healing.

Molecular medicine (Cambridge, Mass.)·2026
Same journal

Folate and global health review series, part 4: syntheses on folate and autoimmune diseases and skeletal outcomes.

Journal of global health·2026
Same journal

Persistent postpartum depressive symptoms and developmental impairment in Bangladeshi children: a cohort study.

Journal of global health·2026
Same journal

Leapfrogging medical infrastructure: a novel bilateral exchange model driven by digital medicine in Kazakhstan.

Journal of global health·2026
Same journal

Navigating the path forward: advancing global health in a changing world - the 31st Canadian Conference on Global Health in 2025.

Journal of global health·2026
Same journal

Global associations of adolescent health with inclusive and sustainable well-being, 2010-2035.

Journal of global health·2026
Same journal

Conjoint association of gestational diabetes mellitus and hypertensive disorders of pregnancy with long-term risk of mortality: a population-based cohort study.

Journal of global health·2026
查看所有相关文章

相关实验视频

Updated: Jun 12, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

353

甲状腺功能,体力活动和久坐行为:双向的双样本孟德尔随机化研究.

Chenyu Zhang1, Yutong Han1, Xiaotong Gao2

  • 1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Hospital of China Medical University, Shenyang, Liaoning, China.

Journal of global health
|September 26, 2024
PubMed
概括
此摘要是机器生成的。

较高的甲状腺刺激激素 (TSH) 水平因果上会增加休时间 (LST),这表明甲状腺功能会影响身体活动. 身体质量指数 (BMI) 并没有调解这种关系.

更多相关视频

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

780

相关实验视频

Last Updated: Jun 12, 2025

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse
04:05

Author Spotlight: Accurately Assessing Thyroid Hormone-Driven Motor Alterations in Mouse

Published on: October 6, 2023

353
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.1K
Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
04:14

Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model

Published on: October 6, 2023

780

科学领域:

  • 内分泌学 在内分泌学.
  • 遗传学 是一个遗传学.
  • 公共卫生 公共卫生

背景情况:

  • 甲状腺功能与体力活动 (PA) 之间的关系尚不清楚.
  • 甲状腺激素,包括甲状腺刺激激素 (TSH) 和自由甲状腺素 (FT4),在新陈代谢和能量消耗中起着至关重要的作用.
  • 每日PA,包括休时间的屏幕时间 (LST) 和中度至强度的体力活动 (MVPA),显著影响整体健康.

研究的目的:

  • 研究基因代理甲状腺相关特征和每日PA测量之间的因果关系.
  • 为了确定甲状腺功能是否影响PA或反之.
  • 探索身体质量指数 (BMI) 在这种关系中的潜在调解作用.

主要方法:

  • 使用双向双样本门德尔随机化 (MR) 分析.
  • 使用全基因组关联研究 (GWAS) 数据用于甲状腺特征和PA测量.
  • 应用逆方差加权 (IVW) 方法与灵敏度分析 (MR-Egger,加权中位数,MR-PRESSO) 和多变量MR (MVMR) 结合与BMI相关的特征.

主要成果:

  • 在基因代理TSH水平增加导致LST增加 (β=0.040,P=9.776×10−5) 的情况下,观察到显著的积极因果作用.
  • 在MVMR分析中,即使考虑到BMI (MVMR-IVW:β=0.042,P=0.007),这种关联仍然显著.
  • 没有证据表明PA因果关系影响甲状腺功能在任何方向.

结论:

  • 甲状腺功能,特别是TSH水平,因果关系影响每日PA,特别是增加LST.
  • 观察到的TSH-LST关联独立于BMI.
  • 这些发现突显出甲状腺功能与身体活动模式之间的单向因果关系.