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卵细胞冷保存在变性人和性别不同的个人与或没有先前使用丸激素
Sarah Capelouto Cromack1, Jessica R Walter, Kristin N Smith
1Division of Reproductive Endocrinology & Infertility, Department of Obstetrics & Gynecology, Northwestern Feinberg School of Medicine, Chicago, Illinois.
Obstetrics and gynecology
|September 26, 2024
概括
卵细胞冷保存对于跨性别和性别多元的人来说是可行的,无论他们以前使用过哪种丸激素. 结冰的成熟卵细胞的生育保存成功率在前不服用丸激素和暴露于丸激素的组之间是相似的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 确认性别的护理
- 在瘤学瘤学.
背景情况:
- 保护生育能力对于接受性别肯定护理的跨性别和性别多元个体至关重要.
- 丸激素治疗可能会影响生殖潜力,需要对卵细胞冷保存结果进行评估.
研究的目的:
- 评估卵细胞冷保存在跨性别和性别多样性青少年和年轻人中的可行性和结果.
- 为了比较具有和没有先前丸激素暴露的个体之间的卵细胞冷保存成功率.
主要方法:
- 35岁以下接受卵细胞冷保存的患者的回顾性队列研究 (2014-2023年).
- 分析包括用于生育保存的患者,区分先验和暴露于的组.
- 测量的主要结果是检索的卵细胞数量和冷的成熟卵细胞数量.
主要成果:
- 追求生育保护的患者数量每年都在增加.
- 在未经测试和暴露于测试的组之间,检测到的卵细胞数量 (中位数为28对32) 或冷的成熟卵细胞 (21对21) 没有显著差异.
- 无论是使用丸激素的持续时间还是停止使用丸激素的时间 (至少2个月) 都没有影响结的成熟卵细胞数量.
结论:
- 卵细胞冷保存是跨性别和性别多样性个体的成功生育保护选择,不管他们之前接触过哪种丸激素.
- 丸激素治疗似乎不会对卵细胞产量或冷保存质量产生负面影响.
- 这项研究支持将卵细胞冷保存作为这种人群的标准生育保护选择.
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