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Updated: Jun 12, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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作为具有潜在抗癌活性的选择性CDK2抑制剂的新型氨酸衍生物:设计,合成和生物评估

Alpesh Shah1, Nishith Teraiya2, Jignesh H Kamdar3

  • 1BRCC Laboratory, Department of Chemistry, School of Science, RK University, Rajkot 360 020, Gujarat, India.

Bioorganic chemistry
|September 26, 2024
PubMed
概括

新的 purin 类似物通过抑制 CDK2 (环素依赖激酶2) 来显示出它们作为抗癌剂的前景. 化合物5g和5i表现出显著的细胞毒性和选择性,需要进一步研究作为潜在的癌症治疗药物.

关键词:
细胞灭亡 (apoptosis) 是一种死亡的过程.抑制CDKs的抑制作用停靠研究对接研究纯氨酸核酸是一种纯氨酸核酸.

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