青铜时代的奶酪揭示了人类与乳杆菌在进化历史上的相互作用
Yichen Liu1, Bo Miao2, Wenying Li3
1Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100035, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
Cell
|September 26, 2024
概括
铜器时代的古代DNA揭示了发酵乳制品的新历史. 这项研究揭示了东亚的传播及其微生物因人类活动和环境压力而发生的适应.
科学领域:
- 微生物学
- 古遗传学
- 古代DNA分析
背景情况:
- 发酵乳制品如, 人类消费的历史很长.
- 了解发酵微生物的历史利用和演变仍然有限.
- 之前的研究表明, 酒起源于北高加索地区.
研究的目的:
- 通过古老的DNA分析来探索人类与微生物的相互作用.
- 为了研究的历史传播和演变.
- 了解人类活动在微生物进化中的作用.
主要方法:
- 从青铜时代的奶酪 (∼3,500年前) 提取和分析古老的DNA.
- 古代和现代菌株的比较基因组分析.
- 植物遗传学分析以确定微生物的进化史和传播.
主要成果:
- 鉴定出一个古老的奶酪样品从西墓地约有3,500年前.
- 发现了从新疆到东亚内陆的另一个扩散路线,与之前已知的高加索路线不同.
- 观察到东亚菌株获得了基因集群, 赋予了对环境压力因素的防御作用.
- 推断这些适应可能是由于环境的适应和人类的选择.
结论:
- 过去的人类活动极大地影响了与人类相关的微生物的进化.
- 古代DNA分析为发酵食品的历史传播和适应提供了关键的见解.
- 这项研究提高了我们对人类行为和微生物共同进化的理解.
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