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Updated: Jun 12, 2025

In Vitro Selection of Engineered Transcriptional Repressors for Targeted Epigenetic Silencing
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合理设计未翻译区域以增强基因表达

Mingchun Liu1, Zhuoer Jin1, Qing Xiang1

  • 1College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China.

Journal of molecular biology
|September 26, 2024
PubMed
概括

通过对5'和3'非翻译区域 (UTR) 进行工程来优化信使RNA (mRNA) 结构,可显著提高蛋白质的产生. 关键发现包括5' UTR中最佳间距长度和GC含量以及3' UTR中使用G-四重复合胺体.

关键词:
在 UTR 图案中, UTR 图案是:在mRNA的稳定性上.蛋白质表达 蛋白质表达合理的设计理性的设计.翻译法规 翻译法规

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