鼠前额叶皮的作用和性别差异在决策中的作用
Jensen A Palmer1, Samantha R White1, Kevin Chavez Lopez1
1Department of Neuroscience, American University, Washington, DC 20016.
概括
前皮质 (PLC) 通过控制需要多少证据来选择来调节决策的时间. PLC的失活加快了决策的速度,而μ-阿片类刺激减慢了决策的速度,影响了"何时"的选择,而不是"如何"的选择.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 行为经济学是一种行为经济学.
背景情况:
- 前额叶皮质对于决策至关重要.
- 漂移扩散模型 (DDM) 在决策过程中分析神经计算.
- 有限的研究存在于动物前额叶皮层在决策控制中的作用.
研究的目的:
- 调查前临床皮层 (PLC) 在决策中的作用.
- 在老鼠中使用两种替代性强制选择任务.
- 检查决策行为和神经机制中的性别差异.
主要方法:
- 老鼠执行了一个视觉刺激-奖励值任务.
- DDM分析量化了决策参数.
- 进行了PLC的药理操作 (无活化,μ-阿片类药物刺激).
主要成果:
- 女性的学习速度比男性更快,更有选择性.
- 男性最初的决策值较低;女性的漂移率较高.
- PLC无活化降低了决策值;μ-阿片类药物刺激增加了它们,改变了决策时间而不影响偏好.
结论:
- 该PLC对决策过程进行抑制控制.
- PLC活动调节证据积累值,影响决策时间.
- 控制器决定"何时"采取行动,而不是"如何"选择.
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