多种维生素与自闭症的社会适应能力和严重程度之间的相互作用和关联:来自中国的大规模回顾性研究
Qi Liu1,2, Dongchuan Yu1,2,3
1Henan Provincial Medical Key Lab of Child Developmental Behavior and Learning, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
概括
患有自闭症谱系障碍 (ASD) 的儿童可能有改变的维生素水平. 这项研究发现,特定的维生素度,如维生素A和维生素B12,与ASD儿童的症状严重程度和社会适应能力相关.
科学领域:
- 营养神经科学 营养神经科学
- 发育儿科 发育儿科
- 临床生物化学 临床生物化学
背景情况:
- 自闭症谱系障碍 (ASD) 经常与选择性饮食有关,可能会影响营养状况.
- 之前对ASD患者血清维生素水平的研究已经产生了不一致的结果.
- 多种维生素与ASD特异性症状 (如社会适应能力和严重程度) 之间的相互作用需要进一步研究.
研究的目的:
- 研究血清中叶酸 (FA),维生素A (VA),维生素E (VE),维生素B12 (VB12),维生素D (VD) 和ASD症状严重程度和社会适应能力之间的关联.
- 探索这些维生素之间的相互作用,以了解它们对ASD相关结果的影响.
- 提供基于证据的见解,了解ASD儿童全面维生素评估的作用.
主要方法:
- 对1235名在中国被诊断患有自闭症儿童的大样本进行了横截面调查.
- 测量了FA,VA,VE,VB12和VD的血清水平.
- 统计分析检查了维生素度与ASD症状严重程度和社会适应能力之间的关联和相互作用.
主要成果:
- 较高的VA,VE,VB12和VD血清度与ASD症状严重程度有负相关性.
- 血清中FA和VB12度与社会适应能力有显著的关联.
- 观察到VA和VE之间关于症状严重性的相互作用,以及FA和VB12之间关于社会适应性的相互作用.
结论:
- 血清维生素水平,包括VA,VE,VB12和VD,与ASD儿童的症状严重程度有关.
- FA和VB12在这个人群的社会适应性中发挥着作用.
- 综合考虑多种维生素对于理解ASD中维生素差异和食物选择性至关重要.
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