超神论者与超标论者还是超神论者加上超标论者?
Margarida D Amaral1, Ines Pankonien1
1BioISI- Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisboa, Lisboa, Portugal.
概括
先进的囊性纤维化 (CF) 治疗需要比较细胞系中的类型化和使用患者样本的类型化. 整合这两种方法可能会为所有患有CF的人提供更好的治疗方法.
科学领域:
- 生物医学研究的研究.
- 遗传学 是一个遗传学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 将所有患有囊性纤维化 (pwCF) 的人治疗到高效CFTR调节器疗法 (HEMT) 所获得的益处水平仍然是一个重大挑战.
- 治疗类型和治疗术是促进CF治疗的两种不同的方法.
- 这两种方法在研究和治疗CF时都有独特的优点和局限性.
研究的目的:
- 讨论在使用pwCF衍生生物材料的细胞系和theranostics中进行类型定制的挑战,优点和缺点.
- 为了比较每个方法的生理相关性和患者特异性.
- 为推进CF治疗提出一个综合战略.
主要方法:
- 讨论现有的文献和细胞系中类型化方法.
- 分析使用患者衍生生物材料的治疗术的挑战和好处.
- 对CF研究和治疗的两种方法的比较评估.
主要成果:
- 细胞系中的治疗类型提供了易用性,成本效益和标准化的平台,但缺乏生理相关性和患者特异性.
- 热诺斯蒂克为个性化医疗提供了一个与人类相关的模型,但需要专门的专业知识,资源和患者样本.
- 两种方法都不能完全解决CF治疗的复杂性.
结论:
- 整合治疗类型和治疗学,利用它们各自的优势,可以提高对CF的理解.
- 一种并行方法可以促进所有pwCF开发更有效的疗法.
- 在CF治疗中,个性化医疗策略可以通过组合方法来推进.
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