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使用类固醇治疗慢性鼻炎和过敏鼻炎的大量鼻灌

Giacomo Bertazzoni¹, Carlo Conti^2,3, Gabriele Testa^4,5

¹Department of Otorhinolaryngology, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|September 26, 2024

概括

高容量类固醇鼻灌 (SNI) 与鼻喷雾相比,为慢性鼻炎 (CRS) 和过敏性鼻炎 (AR) 提供了优越的症状缓解. 这种方法是安全的,没有报告显著的系统性副作用,但成本效益需要进一步研究.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
过敏学过敏学
药理学药理学是指药理学的学科.

背景情况:

慢性鼻炎 (CRS) 和过敏性鼻炎 (AR) 是影响生活质量的常见疾病.
目前的治疗方法包括鼻喷雾,但疗效可能有限.
大量的类固醇鼻灌 (SNI) 是一种潜在的替代治疗方式.

研究的目的:

系统地审查大量SNI对CRS和AR的疗效,安全性和成本效益.
为了将SNI与标准鼻喷雾治疗进行比较.
识别当前研究中的差距,特别是在成本效益方面.

主要方法:

使用PubMed对2012年至2024年间发表的研究进行了系统的文献审查.
搜索术语包括过敏性鼻炎,慢性鼻炎和类固醇鼻灌.
选后包括了20项研究,使用Cochrane和ROBINS-I工具评估了偏差风险.

主要成果:

与鼻喷雾剂相比,大量的SNI在改善CRS和AR症状方面表现出更高的疗效,特别是在术后患者中.
在审查的研究中,布德索尼德是最常用的类固醇.
没有观察到显著的下丘脑-垂体-上腺轴抑制或眼内压力的增加,尽管注意到了轻微的不良事件.

结论:

高容量SNI是CRS和AR比标准鼻喷雾剂更有效的治疗方法,特别是在术后.
大量的SNI的安全概况似乎是有利的,没有重大系统性不良影响.
需要进一步的研究来评估大量SNI的成本效益.

关键词:

过敏性鼻炎是一种过敏性鼻炎.慢性鼻炎是什么意思慢性鼻炎鼻腔皮质类固醇是一种鼻腔皮质类固醇.鼻水灌方式鼻水灌方式

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