玻尿酸神经毒素A型在儿科非神经性疗法耐药过活的膀:一个队列研究
Nicklas B Hougaard1,2, Anders Breinbjerg3,4, Konstantinos Kamperis3,4
1Department of Paediatrics and Adolescent Medicine, Aarhus University Hospital, Palle Juul-Jensens, Boulevard 99, 8200, Aarhus N, Denmark. nikhns@rm.dk.
International urology and nephrology
|September 26, 2024
概括
内毒素神经毒素A型 (BoNT-A) 注射有效地减少过度活动膀 (OAB) 的儿童的尿失禁. 正常的囊泡计 compliance 预测治疗成功,大多数儿童需要重复治疗以获得持续的缓解.
科学领域:
- 儿科泌尿外科 儿科泌尿外科
- 尿动力学 尿动力学 尿动力学
- 药理干预药理干预
背景情况:
- 过度活性膀 (OAB) 和耐火性尿失禁显著影响儿童的生活质量.
- 毒神经毒素类型A (BoNT-A) 是一种新兴的治疗方法,但证据有限.
- 了解疗效和副作用的预测因素对于优化儿科OAB的BoNT-A治疗至关重要.
研究的目的:
- 为了评估内突变体内BoNT-A注射在患有耐火性OAB和尿失禁的儿童中的有效性和安全性.
- 为了确定治疗疗效和与BoNT-A相关的不良事件的预测因素.
- 评估效果的持续时间和需要重复治疗的需要.
主要方法:
- 一项队列研究包括43名患有耐火性OAB和尿失禁的儿童 (平均年龄为10.7岁),不包括患有神经性膀的儿童.
- 在2016年1月至2020年12月期间,注射了intradetrusor BoNT-A注射剂.
- 主要终点:减少尿失禁事件. 二级终点:尿动力学参数,尿液流量计和副作用.
主要成果:
- 第一次治疗后,58%的白天尿失禁患者和47%的夜间尿尿失禁患者的发作减少了≥50%.
- 副作用,主要是尿路感染,发生在16%的患者中.
- 鉴定出正常的囊泡测量符合性是治疗反应的重要预测因素. 平均效果持续时间约为7个月.
结论:
- 内注射器BoNT-A注射是儿童耐火性OAB和尿失禁的安全有效治疗方法.
- 正常的囊泡测量遵守是成功结果的关键预测因素.
- 大多数儿科患者需要重复治疗,突出需要持续管理和进一步研究预测因素.
相关概念视频
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